Sytenol® A by Sytheon is scientifically validated at the mechanism of action, bioactivity and clinical stages. Explore the science below, request a sample, or see how it works in a formula by requesting the formulation guide.
A compound’s gene expression profile is considered a molecular signature.
A microarray experiment comparing Sytenol® A and retinol revealed that, despite their lack of structural similarity, they both demonstrate a similar pattern of activity on key anti-aging genes and proteins.
Double-blind clinical study
Sytenol® A vs. retinol in cream format at the same concentration (0.5%)
This was a randomized, double-blind, 12-week study in which 44 subjects were asked to apply either 0.5% Bakuchiol cream twice daily or 0.5% retinol cream daily. A facial photograph and analysis system was used to obtain and analyze high-resolution photographs of subjects at 0, 4, 8, and 12 weeks.
Bakuchiol and retinol both significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds. The retinol users reported more facial skin scaling and stinging than Sytenol® A.
UC Davis dermatologists ultimately concluded that Sytenol® A could effectively improve the signs of aging in the skin, making it one alternative that’s better tolerated by the skin than retinol.
After this publication in the British Journal of Dermatology (2019), Sytenol® A gained popularity in the media and was named among the trendiest ingredients in 2019 by Mintel.
As an alternative to retinol, Sytenol® A stimulates key anti-aging genes, including:
Sytenol® A also possesses powerful antioxidant properties that help slow the aging process by limiting direct oxidative damage to cells, proteins, and DNA.
Additionally, it helps protect the extracellular matrix and dermo-epidermal junction genes by reducing matrix metalloprotease (MMP) activity, while controlling inflammation to combat the effects of inflammaging.
Sytenol® A is The Real Bakuchiol that reduces wrinkles, photoaging and hyperpigmentation as efficiently as retinol, but with a better skin tolerance.