How Does Bakuchiol Work?

99%+ pure Bakuchiol. 100% clinically proven.

Sytenol® A Bakuchiol by Sytheon is scientifically validated at the mechanism of action, bioactivity and clinical stages. Explore the science below, request a sample, or see how it works in a formula by requesting the formulation guide.

A real alternative to retinol – proven by Sytheon innovators

A compound’s gene expression profile is considered a molecular signature. 

A microarray experiment comparing Sytenol® A Bakuchiol and retinol revealed that, despite their lack of structural similarity, they both demonstrate a similar pattern of activity on key anti-aging genes and proteins.

sytenol a bakuchiol vs retinol gene expression profile graph

A volcano plot showing key genes modulated by Sytenol® A and retinol.

Proof-of-Concept Clinical Study

Anti-Aging Clinical Study

Validated by UC Davis Dermatologists​

Double-blind clinical study

Sytenol® A Bakuchiol vs. retinol in cream format at the same concentration (0.5%)


This was a randomized, double-blind, 12-week study in which 44 subjects were asked to apply either 0.5% Sytenol® A Bakuchiol cream twice daily or 0.5% retinol cream daily. A facial photograph and analysis system was used to obtain and analyze high-resolution photographs of subjects at 0, 4, 8, and 12 weeks.


Sytenol® A Bakuchiol and retinol both significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds. The retinol users reported more facial skin scaling and stinging than Sytenol® A Bakuchiol.

  • Photoaging
    About 20% reduction in wrinkle surface area after 12 weeks for both active ingredients
  • Hyperpigmentation
    59% reduction in hyperpigmentation after 12 weeks for Sytenol® A Bakuchiol whereas 44% for Retinol
  • Skin Scaling & Stinging
    The retinol users reported more facial skin scaling and stinging than Sytenol® A Bakuchiol by a factor of 3 to 5 folds more in a 12-week study.


UC Davis dermatologists ultimately concluded that Sytenol® A Bakuchiol could effectively improve the signs of aging in the skin, making it one alternative that’s better tolerated by the skin than retinol.

After this publication in the British Journal of Dermatology (2019), Sytenol® A Bakuchiol gained popularity in the media and was named among the trendiest ingredients in 2019 by Mintel.

Backed By Science. Trusted By Experts.

Stimulating Key Genes for Graceful Aging

As an alternative to retinol, Sytenol® A Bakuchiol stimulates key anti-aging genes, including:

  • Retinol binding & metabolizing genes
  • Extracellular matrix genes & proteins
  • Dermo-epidermal junction genes & proteins
  • Stimulates hydration biomarkers – Hyaluronic acid synthase & Aquaporin 3 genes

Sytenol® A Bakuchiol also possesses powerful antioxidant properties that help slow the aging process by limiting direct oxidative damage to cells, proteins, and DNA.

Additionally, it helps protect the extracellular matrix and dermo-epidermal junction genes by reducing matrix metalloprotease (MMP) activity, while controlling inflammation to combat the effects of inflammaging.

Your customers deserve the real thing

Sytenol® A is The Real Bakuchiol that reduces wrinkles, photoaging and hyperpigmentation as efficiently as retinol, but with a better skin tolerance.